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Individual outcomes vary

Endogenous IL-1 has been reported to be insufficient for activating and recruiting neutrophils, and even high pharmacological doses of IL-1 fail to exacerbate APAP-induced liver injury, indicating that IL-1 signaling is not a critical contributor to APAP-induced hepatotoxicity

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Moreover, an enriched subgroup analysis of the URICOI-ICTUS trial revealed that UA treatment was safe, well-tolerated, and provided substantial benefits of UA in terms of the primary outcome(modified Rankin Scale score at day 90)